SOMNiBUS - Smooth modeling of bisulfite sequencing
This package aims to analyse count-based methylation data on predefined genomic regions, such as those obtained by targeted sequencing, and thus to identify differentially methylated regions (DMRs) that are associated with phenotypes or traits. The method is built a rich flexible model that allows for the effects, on the methylation levels, of multiple covariates to vary smoothly along genomic regions. At the same time, this method also allows for sequencing errors and can adjust for variability in cell type mixture.
Last updated 5 months ago
dnamethylationregressionepigeneticsdifferentialmethylationsequencingfunctionalprediction
1 stars 4.00 score 133 dependenciesfuntooNorm - Normalization Procedure for Infinium HumanMethylation450 BeadChip Kit
Provides a function to normalize Illumina Infinium Human Methylation 450 BeadChip (Illumina 450K), correcting for tissue and/or cell type.
Last updated 5 months ago
dnamethylationpreprocessingnormalization
3.70 score 138 dependencies